[HTML][HTML] Reduced emergent character of neural dynamics in patients with a disrupted connectome

AI Luppi, PAM Mediano, FE Rosas, J Allanson… - Neuroimage, 2023 - Elsevier
High-level brain functions are widely believed to emerge from the orchestrated activity of
multiple neural systems. However, lacking a formal definition and practical quantification of …

Does the regulation of local excitation–inhibition balance aid in recovery of functional connectivity? A computational account

A Vattikonda, BR Surampudi, A Banerjee, G Deco… - Neuroimage, 2016 - Elsevier
Computational modeling of the spontaneous dynamics over the whole brain provides critical
insight into the spatiotemporal organization of brain dynamics at multiple resolutions and …

Multiscale effects of excitatory-inhibitory homeostasis in lesioned cortical networks: A computational study

F Páscoa dos Santos, J Vohryzek… - PLOS Computational …, 2023 - journals.plos.org
Stroke-related disruptions in functional connectivity (FC) often spread beyond lesioned
areas and, given the localized nature of lesions, it is unclear how the recovery of FC is …

Cognitive flexibility through metastable neural dynamics is disrupted by damage to the structural connectome

PJ Hellyer, G Scott, M Shanahan… - Journal of …, 2015 - Soc Neuroscience
Current theory proposes that healthy neural dynamics operate in a metastable regime,
where brain regions interact to simultaneously maximize integration and segregation …

[HTML][HTML] The application of a mathematical model linking structural and functional connectomes in severe brain injury

A Kuceyeski, S Shah, JP Dyke, S Bickel… - NeuroImage: Clinical, 2016 - Elsevier
Following severe injuries that result in disorders of consciousness, recovery can occur over
many months or years post-injury. While post-injury synaptogenesis, axonal sprouting and …

Dynamical signatures of structural connectivity damage to a model of the brain posed at criticality

A Haimovici, P Balenzuela, E Tagliazucchi - Brain connectivity, 2016 - liebertpub.com
Synchronization of brain activity fluctuations is believed to represent communication
between spatially distant neural processes. These interareal functional interactions develop …

Recovery of neural dynamics criticality in personalized whole-brain models of stroke

RP Rocha, L Koçillari, S Suweis… - Nature …, 2022 - nature.com
The critical brain hypothesis states that biological neuronal networks, because of their
structural and functional architecture, work near phase transitions for optimal response to …

Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome

TH Alderson, ALW Bokde, JAS Kelso, L Maguire… - Neuroimage, 2018 - Elsevier
Current theory suggests brain regions interact to reconcile the competing demands of
integration and segregation by leveraging metastable dynamics. An emerging consensus …

Modeling the outcome of structural disconnection on resting-state functional connectivity

J Cabral, E Hugues, ML Kringelbach, G Deco - Neuroimage, 2012 - Elsevier
A growing body of experimental evidence suggests that functional connectivity at rest is
shaped by the underlying anatomical structure. Furthermore, the organizational properties of …

A synergistic workspace for human consciousness revealed by integrated information decomposition

AI Luppi, PAM Mediano, FE Rosas, J Allanson… - BioRxiv, 2020 - biorxiv.org
A central goal of neuroscience is to understand how the brain synthesises information from
multiple inputs to give rise to a unified conscious experience. This process is widely …