PT Foteinou, SE Calvano, SF Lowry… - Mathematical …, 2009 - Elsevier
A receptor mediated model of endotoxin-induced human inflammation is proposed. The activation of the innate immune system in response to the endotoxin stimulus involves the …
R Zamora, S Korff, Q Mi, D Barclay… - PLoS Computational …, 2018 - journals.plos.org
Bacterial lipopolysaccharide (LPS) induces an acute inflammatory response across multiple organs, primarily via Toll-like receptor 4 (TLR4). We sought to define novel aspects of the …
Y Vodovotz - Immunologic research, 2006 - Springer
Various stresses elicit an acute, complex inflammatory response, leading to healing but sometimes also to organ dysfunction and death. We constructed both equation-based …
Inflammation is a complex, non-linear process central to many of the diseases that affect both developed and emerging nations. A systems-based understanding of inflammation …
VA Folcik, G Broderick, S Mohan, B Block… - Theoretical Biology and …, 2011 - Springer
Background The immune system behaves like a complex, dynamic network with interacting elements including leukocytes, cytokines, and chemokines. While the immune system is …
Y Vodovotz, CC Chow, J Bartels, C Lagoa, JM Prince… - Shock, 2006 - journals.lww.com
Trauma and hemorrhagic shock elicit an acute inflammatory response, predisposing patients to sepsis, organ dysfunction, and death. Few approved therapies exist for these …
Y Vodovotz, G An - Systems biology in drug discovery and development …, 2010 - Springer
Inflammation is a complex, multiscale biological response to threats–both internal and external–to the body, which is also required for proper healing of injured tissue. In turn …
We are now standing at the cusp of systems-based understanding of the processes that underlie, drive, and control the acute inflammatory response. Based on decades of …
Inflammation is a normal, robust physiological process. It can also be viewed as a complex system that senses and attempts to resolve homeostatic perturbations initiated from within …