Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies
M Traylor, M Farrall, EG Holliday, C Sudlow… - The Lancet …, 2012 - thelancet.com
Background Various genome-wide association studies (GWAS) have been done in
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …
Advances in genomic analysis of stroke: what have we learned and where are we headed?
As a result of technological advances, the genomic analysis of stroke has shifted from
candidate gene association studies to genome-wide association studies (GWAS). Agnostic …
candidate gene association studies to genome-wide association studies (GWAS). Agnostic …
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
M Matarín, WM Brown, S Scholz… - The Lancet …, 2007 - thelancet.com
Background Despite evidence of a genetic role in stroke, the identification of common
genetic risk factors for this devastating disorder remains problematic. We aimed to identify …
genetic risk factors for this devastating disorder remains problematic. We aimed to identify …
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study
Background The discovery of disease-associated loci through genome-wide association
studies (GWAS) is the leading genetic approach to the identification of novel biological …
studies (GWAS) is the leading genetic approach to the identification of novel biological …
Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African Americans
Background and Purpose—The majority of genome-wide association studies (GWAS) of
stroke have focused on European-ancestry populations; however, none has been …
stroke have focused on European-ancestry populations; however, none has been …
Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations
Background and Purpose—The contribution of genetics to stroke risk, and whether this
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …
differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis …
Stroke genetics: discovery, insight into mechanisms, and clinical perspectives
S Debette, HS Markus - Circulation Research, 2022 - Am Heart Assoc
Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …
condition. In this review, we provide an overview of the current knowledge on monogenic …
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
G Chauhan, CR Arnold, AY Chu, M Fornage… - The Lancet …, 2016 - thelancet.com
Background Genetic determinants of stroke, the leading neurological cause of death and
disability, are poorly understood and have seldom been explored in the general population …
disability, are poorly understood and have seldom been explored in the general population …