The many facets of immune-mediated thrombocytopenia: Principles of immunobiology and immunotherapy

T Moulinet, A Moussu, L Pierson, S Pagliuca - Blood Reviews, 2023 - Elsevier
Immune thrombocytopenia (ITP) is a rare autoimmune condition, due to peripheral platelet
destruction through antibody-dependent cellular phagocytosis, complement-dependent …

Immune thrombocytopenia: recent progress in pathophysiology and treatment

U Abadi, O Yarchovsky-Dolberg… - Clinical and Applied …, 2015 - journals.sagepub.com
Immune thrombocytopenia (ITP) is a rare autoimmune disorder with an incidence of 3 to 5
per 100 000 individuals. In children, the disease is self-limited and is most commonly virus …

Diagnosis and classification of immune-mediated thrombocytopenia

E Lo, S Deane - Autoimmunity reviews, 2014 - Elsevier
Immune thrombocytopenia, or ITP, has been recognized as a clinical entity for centuries, and
the importance of humoral mechanisms in the pathophysiology of ITP has been recognized …

[HTML][HTML] Immune thrombocytopenia: recent advances in pathogenesis and treatments

S Audia, M Mahévas, M Nivet, S Ouandji… - …, 2021 - journals.lww.com
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral
destruction of platelets and an inappropriate bone marrow production. Although the primary …

[HTML][HTML] Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP)

A Zufferey, R Kapur, JW Semple - Journal of clinical medicine, 2017 - mdpi.com
Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Current treatment options for primary immune thrombocytopenia

A Salama - Expert review of hematology, 2011 - Taylor & Francis
Traditional treatment of primary (idiopathic) immune thrombocytopenia (ITP) predominantly
consists of immune suppression and/or modulation. In addition, many treated patients …

[HTML][HTML] Pathophysiology, Clinical Manifestations and Diagnosis of Immune Thrombocytopenia: Contextualization from a Historical Perspective

D Martínez-Carballeira, Á Bernardo, A Caro, I Soto… - Hematology …, 2024 - mdpi.com
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated
decrease in the platelet count and an increased risk of bleeding. The pathogenesis is …

2025 update on clinical trials in immune thrombocytopenia

H Al‐Samkari - American Journal of Hematology, 2024 - Wiley Online Library
Although the development and regulatory approval of the thrombopoietin receptor agonists
revolutionized aspects of the immune thrombocytopenia (ITP) treatment landscape over the …

Advances in the pathophysiology of primary immune thrombocytopenia

M Perera, T Garrido - Hematology, 2017 - Taylor & Francis
Objectives: Classically, immune thrombocytopenia (ITP) was thought to be caused by the
destruction and insufficient production of platelets, as mediated by autoantibodies. More …

Pathogenesis of immune thrombocytopenia

DB Cines, A Cuker, JW Semple - La Presse Médicale, 2014 - Elsevier
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-
mediated platelet destruction. The platelet, as an accessible target, has made ITP an …