Osteoarthritis (OA) is a chronic osteoarthropathy characterized by the progressive
degeneration of articular cartilage and synovial inflammation. Early OA clinical treatments …

Osteoarthritis (OA) is one of the most prevalent chronic joint diseases worldwide, which
causes a series of problems, such as joint pain, muscle atrophy, and joint deformities …

OA is now well accepted as a low-grade inflammatory disease affecting the whole joint. In
addition to mechanical loading, inflammation (particularly synovitis), contributes significantly …

Osteoarthritis (OA) is a common degenerative disease in mammals. However, its
pathogenesis remains unclear. Studies indicate that OA is not only an aging process that but …

Chronic inflammation is implicated in numerous human pathologies. In particular, low-grade
inflammation is currently recognized as an important mechanism of osteoarthritis (OA), at …

Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …

Background and aim Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory
disease; the clinical manifestations are correlated with continuum multiarticular synovitis …

Objectives To investigate the roles and regulatory mechanisms of synovial macrophages
and their polarisation in the development of osteoarthritis (OA). Methods Synovial tissues …

Background Macrophage is a central regulator of innate immunity. Its M2 subsets, such as
interstitial synovial macrophages, have been found to play critical roles in suppressing …

Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …