We present the Polygenic Score (PGS) Catalog (https://www. PGSCatalog. org), an open
resource of published scores (including variants, alleles and weights) and consistently …

Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

The genotyping of millions of human samples has made it possible to evaluate variants
across the human genome for their possible association with risks for numerous diseases …

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …

A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …

In celebration of the 20th anniversary of Nature Reviews Genetics, we asked 12 leading
researchers to reflect on the key challenges and opportunities faced by the field of genetics …

Abstract The Database of Genotypes and Phenotypes (dbGap, http://www. ncbi. nlm. nih.
gov/gap) is a National Institutes of Health-sponsored repository charged to archive, curate …

Genome-wide association studies (GWAS) have revolutionized human genetics. They have
led to the identification of thousands of loci that affect both normal variation and susceptibility …

Genotype–phenotype databases provide information about genetic variation, its
consequences and its mechanisms of action for research and health care purposes. Existing …

Rapid advances in DNA sequencing promise to enable new diagnostics and individualized
therapies. Achieving personalized medicine, however, will require extensive research on …