The connectomics of brain disorders

A Fornito, A Zalesky, M Breakspear - Nature Reviews Neuroscience, 2015 - nature.com
Pathological perturbations of the brain are rarely confined to a single locus; instead, they
often spread via axonal pathways to influence other regions. Patterns of such disease …

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

M Pievani, N Filippini, MP Van Den Heuvel… - Nature Reviews …, 2014 - nature.com
Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

A cross-disorder connectome landscape of brain dysconnectivity

MP van den Heuvel, O Sporns - Nature reviews neuroscience, 2019 - nature.com
Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Microstructure-informed connectomics: enriching large-scale descriptions of healthy and diseased brains

S Lariviere, R Vos de Wael, C Paquola, SJ Hong… - Brain …, 2019 - liebertpub.com
Rapid advances in neuroimaging and network science have produced powerful tools and
measures to appreciate human brain organization at multiple spatial and temporal scales. It …

Towards a biologically annotated brain connectome

V Bazinet, JY Hansen, B Misic - Nature reviews neuroscience, 2023 - nature.com
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …

The human connectome: origins and challenges

O Sporns - Neuroimage, 2013 - Elsevier
The human connectome refers to a map of the brain's structural connections, rendered as a
connection matrix or network. This article attempts to trace some of the historical origins of …

Molecular nexopathies: a new paradigm of neurodegenerative disease

JD Warren, JD Rohrer, JM Schott, NC Fox, J Hardy… - Trends in …, 2013 - cell.com
Neural networks provide candidate substrates for the spread of proteinopathies causing
neurodegeneration, and emerging data suggest that macroscopic signatures of network …

Mechanisms of connectome development

M Kaiser - Trends in Cognitive Sciences, 2017 - cell.com
At the centenary of D'Arcy Thompson's seminal work 'On Growth and Form', pioneering the
description of principles of morphological changes during development and evolution …

From maps to multi-dimensional network mechanisms of mental disorders

U Braun, A Schaefer, RF Betzel, H Tost… - Neuron, 2018 - cell.com
The development of advanced neuroimaging techniques and their deployment in large
cohorts has enabled an assessment of functional and structural brain network architecture at …