To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …

Recent genetic studies have identified some alleles that are associated with higher BMI but
lower risk of type 2 diabetes, hypertension, and heart disease. These “favorable adiposity” …

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-
analysis of 16 genome-wide association studies (GWAS, N= 38,580) informative for adult …

Background Obesity is related to multiple cardiovascular disease (CVD) risk factors as well
as CVD and has a strong familial component. We tested for association between SNPs on …

Background The association between adiposity and cardiometabolic traits is well known
from epidemiological studies. Whilst the causal relationship is clear for some of these traits …

Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat …

To understand the causal role of adiposity and ectopic fat in type 2 diabetes and
cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants …

Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …