A contemporary evidence basis for neoadjuvant chemotherapy in upfront resectable pancreatic adenocarcinoma: a systematic review of the literature

DP Stonko, J He, L Zheng, AB Blair - Journal of Pancreatology, 2020 - mednexus.org
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival. Local
control through surgical resection paired with radiotherapy and chemotherapy comprise the …

Neoadjuvant therapy for resectable pancreatic cancer: a new standard of care. Pooled data from 3 randomized controlled trials

DL Birrer, H Golcher, R Casadei, SR Haile… - Annals of …, 2021 - journals.lww.com
Objective: The aim of this study was to pool data from randomized controlled trials (RCT)
limited to resectable pancreatic ductal adenocarcinoma (PDAC) to determine whether a …

Neoadjuvant and adjuvant chemotherapy in pancreatic cancer

U Klaiber, CS Leonhardt, O Strobel, C Tjaden… - … archives of surgery, 2018 - Springer
Abstract Background Only 15–20% of patients with pancreatic ductal adenocarcinoma
(PDAC) have a resectable tumor at the time of diagnosis. Effective multimodal treatment …

Neoadjuvant treatment in resectable pancreatic cancer. Is it time for pushing on it?

M Vivarelli, F Mocchegiani, D Nicolini, A Vecchi… - Frontiers in …, 2022 - frontiersin.org
Pancreatic resection still represents the only curative option for patients affected by
pancreatic ductal adenocarcinoma (PDAC). However, the association with modern …

A qualitative review of neoadjuvant chemotherapy in resectable pancreatic adenocarcinoma

AB Blair, R Sorber, NS Rozich, RA Burkhart - Pancreas, 2019 - journals.lww.com
The aim of this study was to evaluate outcomes of patients with resectable pancreatic
adenocarcinoma (PDAC) who underwent neoadjuvant chemotherapy. The MEDLINE and …

Neoadjuvant chemotherapy in pancreatic cancer: an appraisal of the current high-level evidence

PC Müller, MC Frey, CM Ruzza, F Nickel, C Jost… - Pharmacology, 2021 - karger.com
At the time of diagnosis, only about 20% of patients with pancreatic ductal adenocarcinoma
(PDAC) have resectable disease. PDAC treatment necessitates a multidisciplinary …

Systemic neoadjuvant chemotherapy in modern pancreatic cancer treatment: a systematic review and meta-analysis

K Rangarajan, PH Pucher… - The Annals of The …, 2019 - publishing.rcseng.ac.uk
Background Pancreatic ductal adenocarcinoma remains a disease with a poor prognosis
despite advances in surgery and systemic therapies. Neoadjuvant therapy strategies are a …

Neoadjuvant chemotherapy and disease recurrence after curative-intent surgery in patients with pancreatic adenocarcinoma: A single-center retrospective review.

K Alhamad, N Alrifai, AA Attah, K Shankar, L Alnimer… - 2021 - ascopubs.org
e18610 Background: Early stage pancreatic ductal adenocarcinoma (PDAC) account for up
to 30% of newly diagnosed patients. Until recently, the mainstay of treatment remained …

Neoadjuvant treatments for pancreatic ductal adenocarcinoma: where we are and where we are going

A Coppola, T Farolfi, V La Vaccara, I Iannone… - Journal of Clinical …, 2023 - mdpi.com
Background: Pancreatic ductal adenocarcinoma (PDAC) represents a challenging disease
for the surgeon, oncologist, and radiation oncologist in both diagnostic and therapeutic …

Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer: a meta-analysis of randomized controlled trials

JM Cloyd, V Heh, TM Pawlik, A Ejaz, M Dillhoff… - Journal of clinical …, 2020 - mdpi.com
The efficacy of neoadjuvant therapy (NT) versus surgery first (SF) for pancreatic ductal
adenocarcinoma (PDAC) remains controversial. A random-effects meta-analysis of only …