A central goal of genetics is to understand the links between genetic variation and disease.
Intuitively, one might expect disease-causing variants to cluster into key pathways that drive …

Susceptibility to common human diseases is influenced by both genetic and environmental
factors. The explosive growth of genetic data, and the knowledge that it is generating, are …

The evidence that most adult-onset common diseases have a polygenic genetic architecture
fully consistent with robust biological systems supported by multiple back-up mechanisms is …

A key goal of biomedical research is to elucidate the complex network of gene interactions
underlying complex traits such as common human diseases. Here we detail a multistep …

The completion of the human genome sequence in 2003 clearly marked the beginning of a
new era for biomedical research. It spurred technological progress that was unprecedented …

Although recent genome-wide studies have provided valuable insights into the genetic basis
of human disease, they have explained relatively little of the heritability of most complex …

Testing hundreds of thousands of DNA markers in human, mouse, and other species for
association to complex traits like disease is now a reality. However, information on how …

There are thousands of known associations between genetic variants and complex human
phenotypes, and the rate of novel discoveries is rapidly increasing. Translating those …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …