The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: clinical implications

P Dumnicka, D Maduzia, P Ceranowicz… - International journal of …, 2017 - mdpi.com
Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild
local inflammation to severe systemic involvement resulting in substantial mortality. Early …

Pathogenesis and therapy of coagulation disorders in severe acute pancreatitis

M Gui, B Zhao, J Huang, E Chen, H Qu… - Journal of Inflammation …, 2023 - Taylor & Francis
Ischemia superimposed upon pancreatic edema leads to acute necrotizing pancreatitis. One
possible mechanism contributing to ischemia is intravascular thrombogenesis since fibrin …

Pathophysiological mechanisms of acute pancreatitis define inflammatory markers of clinical prognosis

GA Minkov, KS Halacheva, YP Yovtchev… - Pancreas, 2015 - journals.lww.com
Abstract Development of acute pancreatitis illustrates the need to understand the basic
mechanisms of disease progression to drive the exploration of therapeutic options …

Coagulation, platelets, and acute pancreatitis

A Kakafika, V Papadopoulos, K Mimidis… - Pancreas, 2007 - journals.lww.com
Acute pancreatitis generates a complex cascade of immunological events that affect the
pathogenesis and the progression of this disease. Several inflammatory mediators seem to …

The clinical course of acute pancreatitis and the inflammatory mediators that drive it

L Kylänpää, Z Rakonczay Jr… - International journal of …, 2012 - Wiley Online Library
Acute pancreatitis (AP) is a common emergency condition. In the majority of cases, it
presents in a mild and self‐limited form. However, about 20% of patients develop severe …

D-dimer in acute pancreatitis: a new approach for an early assessment of organ failure

D Radenkovic, D Bajec, N Ivancevic, N Milic… - Pancreas, 2009 - journals.lww.com
Objectives: Studies on the clinical value of parameters of hemostasis in predicting
pancreatitis-associated complications are still scarce. The aim of this prospective study was …

Multifactorial scores and biomarkers of prognosis of acute pancreatitis: applications to research and practice

P Silva-Vaz, AM Abrantes, M Castelo-Branco… - International journal of …, 2020 - mdpi.com
Acute pancreatitis (AP) is a severe inflammation of the pancreas presented with sudden
onset and severe abdominal pain with a high morbidity and mortality rate, if accompanied by …

Pathogenic mechanisms of acute pancreatitis

RP Sah, P Garg, AK Saluja - Current opinion in gastroenterology, 2012 - journals.lww.com
New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

Acute Pancreatitis: The Pathophysiological Role of Cytokines and Integrins: New Trends for Treatment?

MO Osman, SL Jensen - Digestive surgery, 1999 - karger.com
As Moynihan [1] wrote in 1925,'Acute pancreatitis (AP) is the most terrible of all the
calamities that occur in connection with the abdominal viscera. The suddenness of its onset …

Acute pancreatitis: models, markers, and mediators

J Granger, D Remick - Shock, 2005 - journals.lww.com
Acute pancreatitis has an incidence of approximately 40 cases per year per 100,000 adults.
Although usually self-limiting, 10% to 20% of afflicted patients will progress to severe …