Integration of multi-omics summary data reveals the role of N6-methyladenosine in neuropsychiatric disorders

C Liufu, L Luo, T Pang, H Zheng, L Yang, L Lu… - Molecular …, 2024 - nature.com
Abstract N6-methyladenosine (m6A) methylation regulates gene expression/protein by
influencing numerous aspects of mRNA metabolism and contributes to neuropsychiatric …

Genome-wide identification of m6A-associated single nucleotide polymorphisms in complex diseases of nervous system

F Guo, J Kang, J Xu, S Wei, J Tao, Y Dong, Y Ma… - Neuroscience …, 2023 - Elsevier
Abstract N6-methyladenosine (m 6 A) is one of the most abundant chemical modifications on
RNA and can affect the occurrence and development of diseases. Some studies have …

[HTML][HTML] The progression of N6-methyladenosine study and its role in neuropsychiatric disorders

C Lei, Q Wang - International Journal of Molecular Sciences, 2022 - mdpi.com
Epitranscriptomic modifications can affect every aspect of RNA biology, including stability,
transport, splicing, and translation, participate in global intracellular mRNA metabolism, and …

[HTML][HTML] Influence of N6-methyladenosine (m6A) modification on cell phenotype in Alzheimer's disease

P Ni, K Pan, B Zhao - Plos one, 2023 - journals.plos.org
Objective Recent research has suggested that m6A modification takes on critical
significance to Neurodegeneration. As indicated by the genome-wide map of m6A mRNA …

Integrative Genomic Analysis of m6a-SNPs Identifies Potential Functional Variants Associated with Alzheimer's Disease

SM Jan, A Fahira, Y Shi, MI Khan, A Jamal… - ACS …, 2023 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disorder that affects 35 million people
worldwide. However, no potential therapeutics currently are available for AD because of the …

[HTML][HTML] In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

N Suga, Y Ikeda, S Yoshikawa, K Taniguchi… - Neurology …, 2023 - mdpi.com
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved
in the development of multiple diseases, which might be a prevalent modification of …

[HTML][HTML] The m6A-methylome in major depression: A bioinformatic analysis of publicly available datasets

K Joshi, DO Wang, A Gururajan - Psychiatry Research Communications, 2022 - Elsevier
One of the most common RNA modifications found in the mammalian brain is N6-
methyladenosine (m6A) and this modification has been implicated in fine-tuning neuronal …

[HTML][HTML] DRUM: Inference of Disease-Associated m6A RNA Methylation Sites From a Multi-Layer Heterogeneous Network

Y Tang, K Chen, X Wu, Z Wei, SY Zhang, B Song… - Frontiers in …, 2019 - frontiersin.org
Recent studies have revealed that the RNA N 6-methyladenosine (m6A) modification plays
a critical role in a variety of biological processes and associated with multiple diseases …

Genome-Wide Detection of m6A-Associated Genetic Polymorphisms Associated with Ischemic Stroke

R Zhu, D Tian, Y Zhao, C Zhang, X Liu - Journal of Molecular …, 2021 - Springer
Abstract N 6-Methyladenosine (m 6 A) methylation is the most abundant post-transcription
modification in eukaryotes and plays a vital role in many pathological conditions including …

[HTML][HTML] Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods

SY Zhang, SW Zhang, XN Fan, J Meng… - PLoS computational …, 2019 - journals.plos.org
N6-methyladenosine (m6A) is the most abundant methylation, existing in> 25% of human
mRNAs. Exciting recent discoveries indicate the close involvement of m6A in regulating …