Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels

F Gao, RAE Edden, M Li, NAJ Puts, G Wang, C Liu… - Neuroimage, 2013 - Elsevier
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain.
Although measurements of GABA levels in vivo in the human brain using edited proton …

Reproducibility of prefrontal γ‐aminobutyric acid measurements with J‐edited spectroscopy

M Geramita, JW van der Veen, AS Barnett… - NMR in …, 2011 - Wiley Online Library
Abstract γ‐Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the human
brain, and GABA‐ergic dysfunction has been implicated in a variety of neuropsychiatric …

Grey and white matter GABA level differences in the human brain using two‐dimensional, J‐resolved spectroscopic imaging

JE Jensen, B deB. Frederick… - NMR in Biomedicine: An …, 2005 - Wiley Online Library
A novel, two‐dimensional, J‐resolved chemical‐shift imaging sequence was used to collect
γ‐aminobutyric acid (GABA) spectroscopic imaging data on six healthy subjects at 4 T …

Measurement of variation in the human cerebral GABA level by in vivo MEGA‐editing proton MR spectroscopy using a clinical 3 T instrument and its dependence on …

M Harada, H Kubo, A Nose, H Nishitani… - Human brain …, 2011 - Wiley Online Library
The objectives of this study were to examine the reproducibility of the MEGA‐editing J‐
difference technique and to determine the normal variation in the γ‐aminobutyric acid …

Decreased γ‐aminobutyric acid levels in the parietal region of patients with Alzheimer's disease

X Bai, RAE Edden, F Gao, G Wang… - Journal of Magnetic …, 2015 - Wiley Online Library
Purpose To determine whether there are in vivo differences of γ‐aminobutyric acid (GABA)
levels in frontal and parietal regions of Alzheimer's disease (AD) patients, compared with …

Frontal gamma-aminobutyric acid concentrations are associated with cognitive performance in older adults

EC Porges, AJ Woods, RAE Edden, NAJ Puts… - Biological psychiatry …, 2017 - Elsevier
Background Gamma-aminobutyric acid (GABA), the brain's principal inhibitory
neurotransmitter, has been associated with perceptual and attentional functioning. Recent …

Spectral‐editing measurements of GABA in the human brain with and without macromolecule suppression

AD Harris, NAJ Puts, PB Barker… - Magnetic resonance in …, 2015 - Wiley Online Library
Purpose The conventional spectral‐editing experiment used to measure GABA in the human
brain also contains a contribution from macromolecules (MM), and the combined GABA plus …

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil

KW Waddell, MJ Avison, JM Joers, JC Gore - Magnetic resonance imaging, 2007 - Elsevier
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in human brain and has
been implicated in several neuropsychiatric disorders. In vivo human brain GABA …

Assessment of GABA concentration in human brain using two-dimensional proton magnetic resonance spectroscopy

Y Ke, BM Cohen, JY Bang, M Yang… - Psychiatry Research …, 2000 - Elsevier
A quantitative method to assess in vivo brain gamma-aminobutyric acid (GABA) levels is
proposed using a J-resolved, two-dimensional (2D) magnetic resonance spectroscopy …

Unedited in vivo detection and quantification of γ‐aminobutyric acid in the occipital cortex using short‐TE MRS at 3 T

J Near, J Andersson, E Maron, R Mekle… - NMR in …, 2013 - Wiley Online Library
Short‐TE MRS has been proposed recently as a method for the in vivo detection and
quantification of γ‐aminobutyric acid (GABA) in the human brain at 3 T. In this study, we …