Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

The various protein deposits of brain amyloidosis share common ultrastructural, biophysical,
and histological properties. These amyloidogenic deposits can be composed of distinct …

Alzheimer's disease (AD) is the most widespread form of dementia, characterized by
memory loss and reduction of cognitive functions that strongly interfere with normal daily life …

Studies of neurodegenerative disorders (NDDs) are drawing more attention of researchers
worldwide due to the high incidence of Alzheimer's disease (AD). The pathophysiology of …

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder characterized by
amyloid deposition in the cerebral neuropil and vasculature. These amyloid deposits …

This issue of Acta Neuropathologica includes a cluster of three review papers focusing on
amyloid β-peptide (Aβ) and/or τ-protein aggregates in Alzheimer's disease (AD). Since the …

Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …

Aβ (amyloid β-peptide) and tau are the main proteins that misfold and accumulate in amyloid
plaques and NFTs (neurofibrillary tangles) of Alzheimer's disease and other neurological …

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark
of Alzheimer's disease (AD) neuropathology and reduction of Aβ has become a leading …

Publisher Summary This chapter reviews the emerging understanding of the causes and
mechanism of Alzheimer's disease (AD) that has developed and what it is ultimately likely to …