Schizophrenia is clinically heterogeneous but it is not known whether this is due to the
existence of discrete subtypes. For the purpose of explication,'indicators' of schizophrenia …

To confirm etiological heterogeneity, it is required that schizophrenic patients may be
separated into at least two classes having different known etiologies and, perhaps, different …

Clinical and etiopathological heterogeneity in schizophrenia has been recognized long ago.
The main hypothesis held in this report is that as long as we are not able to disentangle the …

In this paper we consider the generally accepted view that schizophrenia is 'heterogeneous'.
We point out that the view derives from prima facie evidence from clinical presentation …

Despite agreement that chronic schizophrenia is clinically heterogeneous, no system of
subclassification has received general acceptance. Most methods for defining subgroups …

The manifest clinical heterogeneity of schizophrenia, combined with the failure, to date, to
demonstrate the existence of a unitary disease process, has led to the conceptualization of …

During the last two decades, much effort has been made to precisely characterize the
symptom dimensions of schizophrenia. A number of dimensional models have been …

Three main ways of viewing schizophrenia exist that have different prognostic, practical, and
conceptual implications. The mixed cross-sectional/longitudinal view of Kraepelin and …

The rationale and limitations of discriminating between cases of schizophrenia with and
without a family history are reviewed. It is concluded from the evidence available that, by …

Although the clinical presentation and course of schizophrenia is highly variable, it is
unclear whether this reflects heterogeneity at an aetiological level. The genetic evidence is …