Background As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute
Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) …

The overall aim of this project was to investigate the fundamental phenotypic traits of a
cancer cell in order to develop a primary “in silico” simulation model and reinvestigate the …

Background The cell cycle is a complex process that allows eukaryotic cells to replicate
chromosomal DNA and partition it into two daughter cells. A relevant regulatory step is in the …

A part of current research has intensively been focused on the proliferation and metabolic
processes governing biological systems. Since the advent of high throughput methodologies …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. During cell cycle
progression from the mid-to late G 1 phase, mammalian cells traverse the restriction point, a …

Acute lymphoblastic leukemia (ALL) is one of the most common forms of malignancy that
occurs in lymphoid progenitor cells, particularly in children. Synthetic steroid hormones …

A detailed model mechanism for the G1/S transition in the mammalian cell cycle is
presented and analysed by computer simulation to investigate whether the kinetic origins of …

Acute lymphoblastic leukemia is the most common childhood malignancy.
Rhabdomyosarcoma, on the other hand, is a rare type of malignancy which belongs to the …

Manipulation of differentiation programs has therapeutic potential in a spectrum of human
cancers and neurodegenerative disorders. In this study, we integrated computational and …

[en] In this report we present a new multiple-pathway dynamic stochastic model of leukemia
development, which combines and further extends ideas used in: i) models of hematopoietic …