Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Arginase is a metalloenzyme which hydrolyzes L‐arginine to L‐ornithine and urea. Since its
discovery, in the early 1900s, this enzyme has gained increasing attention, as literature …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction
plays an important role in various cardiovascular disorders, including atherosclerosis …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function,
and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …

Endothelial dysfunction and resulting vascular pathology have been identified as an early
hallmark of multiple diseases, including diabetes mellitus. One of the major contributors to …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …