Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms

MA Ciorba, L Konnikova, SA Hirota… - Inflammatory Bowel …, 2024 - academic.oup.com
Preclinical human inflammatory bowel disease (IBD) mechanisms is one of 5 focus areas of
the Challenges in IBD Research 2024 document, which also includes environmental …

Challenges in IBD research: preclinical human IBD mechanisms

TT Pizarro, TS Stappenbeck, F Rieder… - Inflammatory bowel …, 2019 - academic.oup.com
Preclinical human IBD mechanisms is part of five focus areas of the Challenges in IBD
research document, which also include environmental triggers, novel technologies …

Challenges in IBD research: precision medicine

LA Denson, M Curran, DPB McGovern… - Inflammatory bowel …, 2019 - academic.oup.com
Precision medicine is part of five focus areas of the Challenges in IBD research document,
which also includes preclinical human IBD mechanisms, environmental triggers, novel …

Challenges in IBD Research 2024: Precision Medicine

S Syed, BS Boland, LT Bourke, LA Chen… - Inflammatory Bowel …, 2024 - academic.oup.com
Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024
research document, which also includes preclinical human IBD mechanisms, environmental …

Deciphering the different phases of preclinical inflammatory bowel disease

JJ Rudbaek, M Agrawal, J Torres… - Nature Reviews …, 2023 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …

[PDF][PDF] Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships

DR Plichta, DB Graham, S Subramanian, RJ Xavier - Cell, 2019 - cell.com
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

[HTML][HTML] Capturing the biologic onset of inflammatory bowel diseases: impact on translational and clinical science

D Sorrentino, VQ Nguyen, MV Chitnavis - Cells, 2019 - mdpi.com
While much progress has been made in the last two decades in the treatment and the
management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and …

Systems biology in inflammatory bowel diseases: ready for prime time

C Polytarchou, G Koukos… - Current opinion in …, 2014 - journals.lww.com
A systems biology approach could potentially identify the central regulators (hubs) in the IBD
interactome and improve our understanding of the molecular mechanisms involved in IBD …

Molecular pathways controlling barrier function in IBD

R Atreya, MF Neurath - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
Several key studies published in 2014 have shed light on the pathogenesis of IBD by
investigating the molecular mechanisms controlling mucosal homeostasis and intestinal …

Inflammatory bowel disease pathogenesis: where are we?

C Fiocchi - Journal of gastroenterology and hepatology, 2015 - Wiley Online Library
Inflammatory bowel disease (IBD) is presently one of the most investigated human
disorders. Expansion of knowledge of its pathophysiology has helped in developing novel …