Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the
treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been …

NO is produced endogenously from L-arginine by NOSs. Among its multiple activities, the
homeostatic control of the vascular endothelium is crucial for atherosclerosis, a pathogenic …

Nitric oxide (NO) is a soluble gas continuously synthesized from the amino acid L-arginine in
endothelial cells by the constitutive calcium-calmodulin-dependent enzyme nitric oxide …

Endothelial production of nitric oxide (nitrogen monoxide, NO) has become a major research
area in vascular biology. Some of the most important effects that NO exerts in the vascular …

The field of nitric oxide (NO) biomedical research started in the 1970s with the observations
that the chemically unstable gas, NO, could activate cytosolic guanylate cyclase to stimulate …

The structural integrity and functional activity of the endothelium play an important role in
atherogenesis and related adverse outcomes. Cardiovascular disease risk conditions …

Endothelial dysfunction has been shown in a wide range of vascular desorders including
atherosclerosis and related diseases. Here, we examine and address the complex …

Recently, the circulating anion nitrite (NO2¯), the largest physiological reservoir of nitric
oxide (NO) in the body, has revealed itself as a signalling molecule mediating numerous …

Nitric oxide (NO) is generated from l-arginine by the family of isoenzymes called NO
synthases (NOS). Gene cloning has identified neuronal, endothelial and cytokine-inducible …

Endothelial dysfunction defined as the impaired ability of vascular endothelium to stimulate
vasodilation plays a key role in the development of atherosclerosis and in various …