Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and
cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE …

Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …

The impact of apolipoprotein E (ApoE) isoforms on sporadic Alzheimer's disease has long
been studied; however, the influences of apolipoprotein E gene (APOE) on healthy and …

Dementia is one of the major causes of disability in later life, and ischemic heart disease is a
leading cause of morbidity and mortality. Apolipoprotein E (apoE) plays a pivotal role in …

Apolipoprotein (apo) E, a multifunctional protein with central roles in lipid metabolism and
neurobiology, has three common isoforms (apoE2, apoE3, and apoE4) with different effects …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …