Pediatric sepsis is a life-threatening syndrome characterized by abnormal immune response
to infection, resulting in organ failure and mortality. However, the success of regular …

Sepsis contributes to 1 of every 5 deaths globally with 3 million per year occurring in
children. To improve clinical outcomes in pediatric sepsis, it is critical to avoid “one-size-fits …

Background Sepsis poses a grave threat, especially among children, but treatments are
limited due to clinical and biological heterogeneity among patients. Thus, there is an urgent …

Introduction: Pediatric sepsis (PS) is a life-threatening infection associated with high
mortality rates, necessitating a deeper understanding of its underlying pathological …

Background: Sepsis is a life-threatening condition with a dysregulated host response,
causing significant mortality, especially among children. Despite numerous trials, treatments …

Sepsis is a critical global health concern characterized by a dysregulated immune response
to infection, leading to widespread tissue damage, organ failure, and high mortality rates …

Precision medicine approaches may be used to subclassify, risk-stratify, and select pediatric
patients with sepsis who may benefit from new therapies. Application of precision medicine …

Background Though governed by the same underlying biology, the differential physiology of
children causes the temporal evolution from health to a septic/diseased state to follow …

ABSTRACT Objective Thrombotic microangiopathy induced Thrombocytopenia Associated
Multiple Organ Failure and hyperinflammatory Macrophage Activation Syndrome are …

Background Differential expression (DE) analysis of transcriptomic data enables genome-
wide analysis of gene expression changes associated with biological conditions of interest …