The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

The review focuses on the central neuronal circuits involved in energy homeostasis and the
opportunities these offer for pharmacological intervention to decrease feeding behaviour …

In the last thirty years, obesity has reached epidemic proportions and is now regarded as a
major health issue in contemporary society trending to serious economic and social …

Antiobesity medical management has shown unsatisfactory results to date in terms of
efficacy, safety, and long-term maintenance of weight loss. This poor performance could be …

Abstract Purpose of Review There is currently a steep rise in the global prevalence of
obesity. Pharmaceutical therapy is a valuable component of conservative obesity therapy …

The escalating problem of obesity has initiated an unprecedented search for novel anti-
obesity drugs. This article reviews the wealth of central and peripheral targets that have …

There is a huge void in the current pharmacological treatment options for obesity. This gap is
surprising given the high prevalence and associated costs of obesity. Many factors have …

New therapeutic approaches for the treatment of obesity | Science Translational Medicine
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Obesity has become a global epidemic in the modern world, significantly impacting the
global healthcare economy. Lifestyle interventions remain the primary approach to …

Currently, metabolic surgery (MS) constitutes the most effective means for durable weight
loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non …