Immunity in atherosclerosis: focusing on T and B cells

AV Poznyak, EE Bezsonov, TV Popkova… - International Journal of …, 2021 - mdpi.com
Atherosclerosis is the major cause of the development of cardiovascular disease, which, in
turn, is one of the leading causes of mortality worldwide. From the point of view of …

Adaptive response of T and B cells in atherosclerosis

DFJ Ketelhuth, GK Hansson - Circulation research, 2016 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and
accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in …

Inflammation and immune system interactions in atherosclerosis

B Legein, L Temmerman, EAL Biessen… - Cellular and Molecular …, 2013 - Springer
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for
16.7 million deaths each year. The underlying cause of the majority of CVD is …

Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall

DFJ Ketelhuth, GK Hansson - Thrombosis and haemostasis, 2011 - thieme-connect.com
Atherosclerosis is a chronic inflammatory disease. Atherosclerotic plaques contain abundant
immune cells that can dictate and effect inflammatory responses. Among them, T cells are …

The complex role of T-cell-based immunity in atherosclerosis

P Aukrust, K Otterdal, A Yndestad, WJ Sandberg… - Current atherosclerosis …, 2008 - Springer
Although the pathogenic role of T cells in atherogenesis is well established, the function of
the various T-cell subsets is far from clear. Whereas activation of the T-helper type 1 (Th1) …

Humoral and cellular immune responses in atherosclerosis: spotlight on B-and T-cells

P Ponnuswamy, EA Van Vré, Z Mallat, A Tedgui - Vascular pharmacology, 2012 - Elsevier
Despite more than 1 million basic and clinical investigation reports on the mechanism and
clinical outcome of cardiovascular events, the pathogenesis of this multi factorial disease is …

Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets

C Lahoute, O Herbin, Z Mallat, A Tedgui - Nature Reviews Cardiology, 2011 - nature.com
Chronic inflammation drives the development of atherosclerosis, and adaptive immunity is
deeply involved in this process. Initial studies attributed a pathogenic role to T cells in …

Beyond macrophages and T cells: B cells and immunoglobulins determine the fate of the atherosclerotic plaque

H Mangge, F Prüller, W Schnedl, W Renner… - International Journal of …, 2020 - mdpi.com
Atherosclerosis (AS) leading to myocardial infarction and stroke remains worldwide the main
cause for mortality. Vulnerable atherosclerotic plaques are responsible for these life …

The role of T and B cells in human atherosclerosis and atherothrombosis

E Ammirati, F Moroni, M Magnoni… - Clinical & Experimental …, 2015 - academic.oup.com
Far from being merely a passive cholesterol accumulation within the arterial wall, the
development of atherosclerosis is currently known to imply both inflammation and immune …

[HTML][HTML] Atherosclerosis: the involvement of immunity, cytokines and cells in pathogenesis, and potential novel therapeutics

C Su, Y Lu, Z Wang, J Guo, Y Hou, X Wang… - Aging and …, 2023 - ncbi.nlm.nih.gov
As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has
become one of the major cardiovascular diseases (CVD) negatively impacting patients …