Obesity and cancer—mechanisms underlying tumour progression and recurrence

J Park, TS Morley, M Kim, DJ Clegg… - Nature Reviews …, 2014 - nature.com
Over the past several years, the field of cancer research has directed increased interest
towards subsets of obesity-associated tumours, which include mammary, renal …

[HTML][HTML] Obesity, metabolism and the microenvironment: Links to cancer

S Sundaram, AR Johnson, L Makowski - Journal of carcinogenesis, 2013 - ncbi.nlm.nih.gov
Historically, cancer research has focused on identifying mutations or amplification of genes
within the tumor, which informed the development of targeted therapies against affected …

Targeting obesity-related dysfunction in hormonally driven cancers

MM Rubinstein, KA Brown, NM Iyengar - British journal of cancer, 2021 - nature.com
Obesity is a risk factor for at least 13 different types of cancer, many of which are hormonally
driven, and is associated with increased cancer incidence and morbidity. Adult obesity rates …

Obesity: A perfect storm for carcinogenesis

BHL Harris, VM Macaulay, DA Harris… - Cancer and Metastasis …, 2022 - Springer
Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

Obesity and cancer: local and systemic mechanisms

NM Iyengar, CA Hudis… - Annual review of …, 2015 - annualreviews.org
Obesity is a leading modifiable risk factor for the development of several epithelial
malignancies. In addition to increasing risk, obesity also confers worse prognosis for many …

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

EE Calle, R Kaaks - Nature Reviews Cancer, 2004 - nature.com
The prevalence of obesity is rapidly increasing globally. Epidemiological studies have
associated obesity with a range of cancer types, although the mechanisms by which obesity …

Obesity and cancer: mechanistic insights from transdisciplinary studies

EH Allott, SD Hursting - Endocrine-related cancer, 2015 - erc.bioscientifica.com
Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …

Physiological and environmental factors affecting cancer risk and prognosis in obesity

PFS Etet, L Vecchio, AHN Kamdje, PN Mimche… - Seminars in Cancer …, 2023 - Elsevier
Obesity results from a chronic excessive accumulation of adipose tissue due to a long-term
imbalance between energy intake and expenditure. Available epidemiological and clinical …

Obesity and cancer metabolism: a perspective on interacting tumor–intrinsic and extrinsic factors

SS Doerstling, CH O'Flanagan, SD Hursting - Frontiers in oncology, 2017 - frontiersin.org
Obesity is associated with increased risk and poor prognosis of many types of cancers.
Several obesity-related host factors involved in systemic metabolism can influence tumor …

Obesity and cancer mechanisms: cancer metabolism

BD Hopkins, MD Goncalves, LC Cantley - Journal of clinical oncology, 2016 - ascopubs.org
Obesity is a risk factor for cancer development and is associated with poor prognosis in
multiple tumor types. The positive energy balance linked with obesity induces a variety of …