Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
E Guma, M Bordeleau… - Proceedings of the …, 2022 - National Acad Sciences
Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult …
neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult …
Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioral, and …
E Guma, P do Couto Bordignon, GA Devenyi… - Biological …, 2021 - Elsevier
Background Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental disorders later in life. The impact of the gestational timing of MIA …
neurodevelopmental disorders later in life. The impact of the gestational timing of MIA …
Maternal immune activation during pregnancy alters postnatal brain growth and cognitive development in nonhuman primate offspring
Human epidemiological studies implicate exposure to infection during gestation in the
etiology of neurodevelopmental disorders. Animal models of maternal immune activation …
etiology of neurodevelopmental disorders. Animal models of maternal immune activation …
Sequential perturbations to mouse corticogenesis following in utero maternal immune activation
CP Canales, ML Estes, K Cichewicz, K Angara… - Elife, 2021 - elifesciences.org
In utero exposure to maternal immune activation (MIA) is an environmental risk factor for
neurodevelopmental and neuropsychiatric disorders. Animal models provide an opportunity …
neurodevelopmental and neuropsychiatric disorders. Animal models provide an opportunity …
[HTML][HTML] The long-term impact of elevated C-reactive protein levels during pregnancy on brain morphology in late childhood
Importance Animal studies show that Maternal Immune Activation (MIA) may have
detrimental effects on fetal brain development. Clinical studies provide evidence for …
detrimental effects on fetal brain development. Clinical studies provide evidence for …
Maternal immune activation alters fetal brain development and enhances proliferation of neural precursor cells in rats
KJ Baines, DM Hillier, FL Haddad… - Frontiers in …, 2020 - frontiersin.org
Maternal immune activation (MIA) caused by exposure to pathogens or inflammation during
critical periods of neurodevelopment is a major risk factor for behavioral deficits and …
critical periods of neurodevelopment is a major risk factor for behavioral deficits and …
[HTML][HTML] Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the …
RM Woods, JM Lorusso, HG Potter, JC Neill… - Neuroscience & …, 2021 - Elsevier
Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …
[HTML][HTML] Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model
MD Bauman, J Van de Water - Neurobiology of disease, 2020 - Elsevier
The prenatal environment, and in particular, the maternal-fetal immune environment, has
emerged as a targeted area of research for central nervous system (CNS) diseases with …
emerged as a targeted area of research for central nervous system (CNS) diseases with …
A comprehensive approach to modeling maternal immune activation in rodents
MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …
Maternal immune activation in neurodevelopmental disorders
Converging lines of evidence from basic science and clinical studies suggest a relationship
between maternal immune activation (MIA) and neurodevelopmental disorders such as …
between maternal immune activation (MIA) and neurodevelopmental disorders such as …