Association of Polygenic Variants with type 2 diabetes risk and their interaction with lifestyles in Asians

HJ Hur, HJ Yang, MJ Kim, KH Lee, MS Kim, S Park - Nutrients, 2022 - mdpi.com
Over the last several decades, there has been a considerable growth in type 2 diabetes
(T2DM) in Asians. A pathophysiological mechanism in Asian T2DM is closely linked to low …

[HTML][HTML] Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 Chinese adults: results from 2 independent Asian cohorts

H Li, CC Khor, J Fan, J Lv, C Yu, Y Guo, Z Bian… - The American journal of …, 2020 - Elsevier
Background Whether genetic susceptibility to type 2 diabetes is modified by a healthy
lifestyle among Chinese remains unknown. Objectives The aim of the study was to …

Analysis of ancestry-specific polygenic risk score and diet composition in type 2 diabetes

DS Hardy, JT Garvin, TB Mersha - Plos one, 2023 - journals.plos.org
Background Carbohydrate and protein dietary proportions have been debated as to whether
higher or lower levels are optimal for diabetes metabolic control. Objective The objective of …

Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits

H Yaghootkar, TM Frayling - Genome biology, 2013 - Springer
Recent progress in the use of genetics to understand links between type 2 diabetes and
related metabolic traits | Genome Biology Skip to main content SpringerLink Account Menu …

Gene–diet interactions on metabolic disease-related outcomes in Southeast Asian populations: a systematic review

P Sekar, EF Ventura, ACTA Dhanapal, ESG Cheah… - Nutrients, 2023 - mdpi.com
Diabetes and obesity are chronic diseases that are a burden to low-and middle-income
countries. We conducted this systematic review to understand gene–diet interactions …

Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women

R Villegas, R Delahanty, YT Gao, J Long, SM Williams… - PloS One, 2012 - journals.plos.org
More than 40 genetic susceptibility loci have been reported for type 2 diabetes (T2D).
Recently, the combined effect of genetic variants has been investigated by calculating a …

Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study

Z Chen, MA Pereira, M Seielstad, WP Koh, ES Tai… - PLoS …, 2014 - journals.plos.org
Background Genome-wide association studies (GWAS) have identified genetic factors in
type 2 diabetes (T2D), mostly among individuals of European ancestry. We tested whether …

[HTML][HTML] The complex interplay of genetic and lifestyle risk factors in type 2 diabetes: an overview

PW Franks - Scientifica, 2012 - hindawi.com
Type 2 diabetes (T2D) is one of the scourges of modern times, with many millions of people
affected by the disease. Diabetes occurs most frequently in those who are overweight or …

Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals

K Linder, R Wagner, E Hatziagelaki, C Ketterer… - PLoS …, 2012 - journals.plos.org
Introduction Single nucleotide polymorphisms (SNPs) in approximately 40 genes have been
associated with an increased risk for type 2 diabetes (T2D) in genome-wide association …

Interactions among the variants of insulin-related genes and nutrients increase the risk of type 2 diabetes

KW Hong, SH Kim, X Zhang, S Park - Nutrition research, 2018 - Elsevier
Asians easily develops type 2 diabetes (T2DM) since they have insufficient glucose-
stimulated insulin secretion (GSIS) in insulin resistant states. Since this may be associated …