Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …

The new coronavirus COVID-19 has spread globally and caused a pneumonia outbreak.
Although the whole genome sequences of COVID-19 have been rapidly obtained …

We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated …

Summary The coronavirus disease 2019 (COVID-19) pandemic poses a current world-wide
public health threat. However, little is known about its hallmarks compared to other infectious …

Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines,
but the production of type I interferons, which are key antiviral mediators, is reportedly …

Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …

The mechanisms underlying the immune remodeling and severity response in coronavirus
disease 2019 (COVID-19) are yet to be fully elucidated. Our comprehensive integrative …

Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …

A central paradigm of immunity is that interferon (IFN)-mediated antiviral responses precede
pro-inflammatory ones, optimizing host protection and minimizing collateral damage,. Here …