We tested the hypothesis whether calcium preconditioning (CPC) reduces reoxygenation
injury by inhibiting mitochondrial permeability transition (MPT). Cultured myocytes were …

The mitochondrial permeability transition (MPT) is implicated in cardiac reperfusion/
reoxygenation injury. In isolated ventricular myocytes, the sulfhydryl (SH) group modifier and …

Experimental and clinical studies demonstrated that postconditioning confers protection
against myocardial ischemia/reperfusion injury. However the underlying cellular …

Ca2+ is the main trigger for mitochondrial permeability transition pore opening, which plays
a key role in cardiomyocyte death after ischemia-reperfusion. We investigated whether a …

The objective of the present study was to determine whether the mitochondrial calcium
uniporter plays a role in the cardioprotection induced by ischemic preconditioning (IPC) …

Cardiac ischemia damages the mitochondrial electron transport chain and the damage
persists during reperfusion. Ischemic postconditioning (PC), applied during early …

Objective: We investigated whether ischemic preconditioning (PC) may modify mitochondrial
permeability transition (MPT) pore opening. Methods: In protocol 1, New Zealand White …

We have shown that intermittent interruption of immediate reflow at reperfusion (ie,
postconditioning) reduces infarct size in in vivo models after ischemia. Cardioprotection of …

Mitochondrial permeability transition (mPT) is a crucial event in the progression to cell death
in the setting of ischemia-reperfusion. We have used a model system in which mPT can be …

Aims Resuscitated cardiac arrest (CA), leading to harmful cardiovascular dysfunction and
multiple organ failure, includes a whole-body hypoxia–reoxygenation phenomenon …