Context Chronic kidney disease (CKD) is a public health burden worldwide. Epidemiological
studies observed an association between sex hormones, including estradiol, and kidney …

Background Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid
progress in men than in women. Whether the well-established sex-specific evolutionary …

Aims/hypothesis Reasons for the sexual disparity in chronic kidney disease (CKD) are
unclear. To provide insight we contextualised these differences within evolutionary biology …

Objective Chronic kidney disease (CKD) is a condition influenced by both genetic and
environmental factors and has been a focus of extensive research. Utilizing Mendelian …

Background Despite the potential demonstrated by targeted plasma metabolite modulators
in halting the progression of chronic kidney disease (CKD), a lingering uncertainty persists …

Context Younger women have a slower progressive loss of kidney function than age-
matched men and the sex advantage diminishes after menopause, suggesting a role for …

Background: Uncertainty in the mechanism and directionality of observational associations
between thyroid function and kidney function may be addressed by genetic analysis with an …

Chronic kidney disease (CKD) concerns about 10% of the population in Switzerland.
Epidemiological studies suggest that women are less prone to the development of CKD than …

Gender affects the progression of renal disease. In a variety of animal models and in certain
human renal diseases, females exhibit a more modest course of kidney disease. Estrogens …

Context Despite sex differences in chronic kidney disease (CKD) onset and progression, it is
unclear whether endogenous sex hormones are associated with kidney function in persons …