The paracellular passage of ions and small molecules across epithelia is controlled by tight
junctions, complex meshworks of claudin polymers that form tight seals between …

Tight junctions are macromolecular structures that traverse the space between adjacent
cells in epithelia and endothelia. Members of the claudin family are known to determine tight …

Tight junctions regulate paracellular permeability size and charge selectively. Models have
been proposed for the molecular architecture of tight junction strands and paracellular …

Claudin family tight junction proteins form charge-and size-selective paracellular channels
that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is …

Claudin was first identified as a four-transmembrane protein in the tight junctions (TJs)
between epithelial cells. The claudin family has 27 members, which are specifically …

Intercellular tight junctions form selectively permeable barriers that seal the paracellular
space. Trans-tight junction flux has been measured across large epithelial surfaces, but …

Tight junctions form selectively permeable seals across the paracellular space. Both barrier
function and selective permeability have been attributed to members of the claudin protein …

Barrier properties of tight junctions are determined by the claudin protein family. Many
claudins seal this barrier, but others form paracellular channels. Among these, no claudins …

Tight junctions restrict the flow of ions and aqueous molecules between cells by forming a
selective barrier to the paracellular pathway. Permeability of the tight junction barrier is …

Tight junctions create a paracellular barrier with physiological properties that differ among
epithelia. Among these differences are electrical resistance and discrimination for solute …