Opioids form an important component of general anesthesia and perioperative analgesia.
Discharge opioid prescriptions are identified as a contributor for persistent opioid use and …

Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

The use of opioids in the perioperative period is associated with respiratory depression,
impaired gastrointestinal function, post-operative nausea and vomiting (PONV), pruritus …

Enhanced recovery pathways have quickly become part of the standard of care for patients
undergoing elective surgery, especially in North America and Europe. One of the central …

Surgical care episodes place opioid-naïve patients at risk for transitioning to new persistent
postoperative opioid use. With one of the central principles being the application of …

In the midst of an epidemic of opioid abuse and overdose-related morbidity and mortality,
the use of opioids remains the most common means of providing analgesia in the …

The drug-induced, reversible coma of anaesthesia requires three clinical outcomes:
unconsciousness, immobility, and the control of autonomic nervous system (ANS) responses …

Study Objective: To evaluate the consequences of opioid use for postoperative pain
management and the degree to which these consequences may be reduced or minimized …

Physicians, policymakers, and researchers are increasingly focused on finding ways to
decrease opioid use and overdose in the United States both of which have sharply …

Background Excessive opioid prescribing after surgery has been recognised as a
contributor to the current crisis of opioid addiction and overdose. Clinicians may potentially …