[HTML][HTML] Sotrovimab: A Review of Its Efficacy against SARS-CoV-2 Variants

D Focosi, A Casadevall, M Franchini, F Maggi - Viruses, 2024 - mdpi.com
Among the anti-Spike monoclonal antibodies (mAbs), the S-309 derivative sotrovimab was
the most successful in having the longest temporal window of clinical use, showing a high …

502. early COVID-19 treatment with SARS-CoV-2 neutralizing ANTIBODY SOtrovimab

AK Gupta, YG Rojas, E Juarez, MC Casal… - Open Forum …, 2021 - academic.oup.com
Background COVID-19 disproportionately results in hospitalization and death in older
patients and those with underlying comorbidities. Sotrovimab is a pan-sarbecovirus …

[HTML][HTML] Early treatment for Covid-19 with SARS-CoV-2 neutralizing antibody sotrovimab

A Gupta, Y Gonzalez-Rojas, E Juarez… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background Coronavirus disease 2019 (Covid-19) disproportionately results in
hospitalization or death in older patients and those with underlying conditions. Sotrovimab is …

Safety, virology, pharmacokinetics, and clinical experience of high-dose intravenous sotrovimab for the treatment of mild to moderate COVID-19: an open-label clinical …

J Moya, M Temech, S Parra, E Juarez… - Open Forum …, 2023 - academic.oup.com
Background Five hundred milligrams of intravenous (IV) sotrovimab has been shown to be
well tolerated and efficacious against pre-Omicron strains in treating patients with mild to …

[HTML][HTML] Lack of efficacy for sotrovimab use in patients with COVID-19: a meta-analysis

G Ao, T Li, Y Wang, C Tran, X Qi - The Journal of Infection, 2022 - ncbi.nlm.nih.gov
Dear Editor, We read with great interest the article in this journal by Luo et al. regarding the
use of tocilizumab in patients with COVID-19 infection 1. As the global cases of COVID-19 …

1150. Resistance analysis in the COMET-TAIL study: participants with mild-to-moderate COVID-19 treated with intramuscular or intravenous sotrovimab

ML Agostini, G Schnell, J di Iulio, A Kohli… - Open Forum …, 2022 - academic.oup.com
Abstract Background Sotrovimab (VIR-7831) is an engineered human monoclonal antibody
targeting a conserved region of the SARS-CoV-2 spike protein; it has been shown to have a …

Efficacy and safety of sotrovimab in patients with COVID‐19: A rapid review and meta‐analysis

B Amani, B Amani - Reviews in medical virology, 2022 - Wiley Online Library
The therapeutic potential of sotrovimab in the treatment of coronavirus disease 2019 (COVID‐
19) is a controversial issue. The aim of this study was to evaluate the efficacy and safety of …

[HTML][HTML] What is the efficacy of sotrovimab in reducing disease progression and death in people with COVID-19 during the omicron era? Answers from a real-life study

A De Vito, A Colpani, M Poliseno, L Diella, FRP Ieva… - Viruses, 2023 - mdpi.com
(1) Introduction: Since May 2021, sotrovimab has been available in Italy for early treatment
of SARS-CoV-2 infection and to prevent disease progression. However, some in vitro …

Resistance analysis in the phase III COMET-TAIL study: treatment of COVID-19 with intramuscular or intravenous sotrovimab

ML Agostini, G Schnell, J Iulio, A Kohli, AE Shapiro… - Future …, 2024 - Taylor & Francis
Aim: Sotrovimab, an engineered human monoclonal antibody, targets a conserved region of
the SARS-CoV-2 spike protein. The phase III COMET-TAIL study evaluated noninferiority of …

Resistance analysis following sotrovimab treatment in participants with COVID-19 during the phase III COMET-ICE study

S Subramanian, G Schnell, J Iulio, AK Gupta… - Future …, 2023 - Taylor & Francis
Aim: Sotrovimab is an engineered human monoclonal antibody that binds a conserved
region of the SARS-CoV-2 spike protein. The COMET-ICE phase III study evaluated …