Chronic cortical inflammation, cognitive impairment, and immune reactivity associated with diffuse brain injury are ameliorated by forced turnover of microglia

CE Bray, KG Witcher, D Adekunle-Adegbite… - Journal of …, 2022 - Soc Neuroscience
Traumatic brain injury (TBI) is associated with an increased risk of cognitive, psychiatric, and
neurodegenerative complications that may develop after injury. Increased microglial …

Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia

KG Witcher, CE Bray, T Chunchai, F Zhao… - Journal of …, 2021 - Soc Neuroscience
Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and
neurodegenerative pathologies, which develop and persist years after injury …

Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge

MM Muccigrosso, J Ford, B Benner, D Moussa… - Brain, behavior, and …, 2016 - Elsevier
Traumatic brain injury (TBI) elicits immediate neuroinflammatory events that contribute to
acute cognitive, motor, and affective disturbance. Despite resolution of these acute …

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

RJ Henry, RM Ritzel, JP Barrett, SJ Doran… - Journal of …, 2020 - Soc Neuroscience
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

Long-term cognitive deficits after traumatic brain injury associated with microglia activation

ES Saba, M Karout, L Nasrallah, F Kobeissy… - Clinical …, 2021 - Elsevier
Abstract Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play
an essential role in homeostasis and diseases of the central nervous system. We …

Priming the inflammatory pump of the CNS after traumatic brain injury

KG Witcher, DS Eiferman, JP Godbout - Trends in neurosciences, 2015 - cell.com
Traumatic brain injury (TBI) can lead to secondary neuropsychiatric problems that develop
and persist years after injury. Mounting evidence indicates that neuroinflammatory …

Traumatic brain injury‐induced neuronal damage in the somatosensory cortex causes formation of rod‐shaped microglia that promote astrogliosis and persistent …

KG Witcher, CE Bray, JE Dziabis, DB McKim… - Glia, 2018 - Wiley Online Library
Microglia undergo dynamic structural and transcriptional changes during the immune
response to traumatic brain injury (TBI). For example, TBI causes microglia to form rod …

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia

AM Fenn, JC Gensel, Y Huang, PG Popovich… - Biological …, 2014 - Elsevier
Background Traumatic brain injury (TBI) is associated with a higher incidence of depression.
The majority of individuals who suffer a TBI are juveniles and young adults, and thus, the risk …

[HTML][HTML] Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury

K Krukowski, A Nolan, MK Becker, K Picard… - Brain, behavior, and …, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of long-term neurological disability
in the world. Currently, there are no therapeutics for treating the deleterious consequences …