Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …

Highlights•Heterogeneity in autism spectrum disorder presents a challenge to clinical care
and research.•Genetic sequencing indicates disruptive gene variants and CNVs account for …

A genetic basis for autism spectrum disorder (ASD) is now well established, and with the
availability of high‐throughput microarray and sequencing platforms, major advances have …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication and social interaction and the presence of repetitive …

Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their
risk effects are highly variable, and they are frequently related to other conditions besides …

Although genes have long been appreciated to play a critical role in determining the risk for
pervasive developmental disorders, the specific transcripts contributing to autism spectrum …

Autism is a strongly genetic disorder, with an estimated heritability of greater than 90%.
Nonetheless, its specific genetic etiology remains largely unknown. Over the past several …

Highlights•High throughput genomic methods are rapidly increasing the pool of ASD
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …

The last several years have seen unprecedented advances in deciphering the genetic
etiology of autism spectrum disorders (ASDs). Heritability studies have repeatedly affirmed a …