Given the unprecedented global pandemic of obesity, a better understanding of the etiology
of adiposity will be necessary to ensure effective management of obesity and related …

The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins
through various chaperones and enzymes residing within the ER organelle. Perturbation in …

Obesity challenges lipid and carbohydrate metabolism. The resulting glucolipotoxicity
causes endoplasmic reticulum (ER) dysfunction, provoking the accumulation of immature …

The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded
protein response (UPR), is an adaptive response used to align ER functional capacity with …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The role of endoplasmic reticulum (ER) stress is a rapidly emerging field of interest in the
pathogenesis of metabolic diseases. Recent studies have shown that chronic activation of …

The endoplasmic reticulum (ER) is most notable for its central roles in calcium ion storage,
lipid biosynthesis, and protein sorting and processing. By virtue of its extensive membrane …

In recent years, the world has seen an alarming increase in obesity and closely associated
with insulin resistance which is a state of low-grade inflammation, the latter characterized by …

The endoplasmic reticulum (ER) is the intra-cellular site, where secreted and membrane
proteins are synthesized. ER stress and activation of the unfolded protein response (UPR) …

Background: Obesity is a major risk factor in the development of hepatic insulin resistance,
which is characterized by an impairment of insulin ability to inhibit glucose output. Although …