Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions
that cause liver failure directly or indirectly. Despite significant advances in the field of liver …

Primary liver cancer (PLC) represents a significant proportion of all human cancers and
constitutes a substantial health and economic burden to society. Traditional therapeutic …

Organoid culture systems have emerged as a frontier technology in liver and biliary
research. These three‐dimensional (3D) cell cultures derived from pluripotent and adult …

Human liver cancers, including hepatocellular carcinomas and intra-hepatic
cholangiocarcinomas, are often diagnosed late with poor prognosis. A better understanding …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the second
most frequent cause of cancer-related mortality worldwide. The multikinase inhibitor …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and developing therapies. Here, we review …

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …

Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …

Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …