BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis
R Wang, X Xu, J Yang, W Chen, J Zhao, M Wang… - Journal of hazardous …, 2023 - Elsevier
Abstract Environmental Benzo (a) pyrene (BaP) and its ultimate metabolite BPDE (benzo (a)
pyrene-7, 8-dihydrodiol-9, 10-epoxide) are typical persistent organic pollutants and …
pyrene-7, 8-dihydrodiol-9, 10-epoxide) are typical persistent organic pollutants and …
Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblastic cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway
T Liang, J Xie, J Zhao, W Huang, Z Xu, P Tian… - Cell Biology and …, 2021 - Springer
Normal pregnancy is essential for human reproduction. However, environmental BaP
(benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-dihydrodiol-9, 10 …
(benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-dihydrodiol-9, 10 …
Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage
J Xie, T Liang, J Zhao, Z Xu, P Tian, R Wang… - Cell biology and …, 2022 - Springer
Increasing evidences have shown that pregnant women might miscarry after exposure with
environmental BaP (benzo (a) pyrene). Additionally, BPDE (benzo (a) pyren-7, 8-dihydrodiol …
environmental BaP (benzo (a) pyrene). Additionally, BPDE (benzo (a) pyren-7, 8-dihydrodiol …
Environmental pollutant benzo [a] pyrene upregulated long non-coding RNA HZ07 inhibits trophoblast cell migration by inactivating PI3K/AKT/MMP2 signaling …
Y Ye, S Jiang, T Du, M Ding, M Hou, C Mi, T Liang… - Reproductive …, 2021 - Springer
Abstract Benzo (a) pyrene (BaP) is a ubiquitous environmental endocrine-disrupting
chemical that is known to have toxic effects on reproduction. However, the underlying …
chemical that is known to have toxic effects on reproduction. However, the underlying …
Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive …
Z Xu, P Tian, J Guo, C Mi, T Liang, J Xie… - Science of The Total …, 2021 - Elsevier
Environmental BaP (benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-
dihydrodiol-9, 10-epoxide) inhibit proliferation of human villous trophoblast cells, which …
dihydrodiol-9, 10-epoxide) inhibit proliferation of human villous trophoblast cells, which …
Lnc-HZ05 regulates BPDE-inhibited human trophoblast cell proliferation and affects the occurrence of miscarriage by directly binding with miR-hz05
C Mi, W Chen, T Liang, J Xie, Z Xu, W Huang… - Cell Biology and …, 2022 - Springer
Abstract Approximately 15–25% pregnant women end with miscarriage in the world.
Environmental BaP (benzo (a) pyrene) and its terminal metabolite BPDE (benzo (a) pyrene …
Environmental BaP (benzo (a) pyrene) and its terminal metabolite BPDE (benzo (a) pyrene …
Benzo (a) pyren-7, 8-dihydrodiol-9, 10-epoxide induces human trophoblast Swan 71 cell dysfunctions due to cell apoptosis through disorder of mitochondrial fission …
W Wang, R Wang, Q Zhang, G Mor, H Zhang - Environmental Pollution, 2018 - Elsevier
Abstract Benzo (a) pyren-7, 8-dihydrodiol-9, 10-epoxide (BPDE) is an endocrine disrupter
and ultimate carcinogenic product of benzo (a) pyrene (BaP). Numerous studies have …
and ultimate carcinogenic product of benzo (a) pyrene (BaP). Numerous studies have …
Environmental pollutant benzo [a] pyrene induces recurrent pregnancy loss through promoting apoptosis and suppressing migration of extravillous trophoblast
Y Ye, S Jiang, C Zhang, Y Cheng… - BioMed research …, 2020 - Wiley Online Library
Objects. To investigate the effects of environmental pollutant benzo (a) pyrene (BaP) and its
metabolite benzo [a] pyrene‐7, 8‐diol‐9, 10‐epoxide (BPDE) on human trophoblasts and on …
metabolite benzo [a] pyrene‐7, 8‐diol‐9, 10‐epoxide (BPDE) on human trophoblasts and on …
BPDE, the Migration and Invasion of Human Trophoblast Cells, and Occurrence of Miscarriage in Humans: Roles of a Novel lncRNA-HZ09
M Dai, W Huang, X Huang, C Ma, R Wang… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Recurrent miscarriage (RM) affects 1%–3% of pregnancies. However, in
almost 50% of cases, the cause is unknown. Increasing evidence have shown that benzo (a) …
almost 50% of cases, the cause is unknown. Increasing evidence have shown that benzo (a) …
Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB …
Y Meng, Z Yannan, L Ren, S Qi, W Wei… - Reproductive Toxicology, 2020 - Elsevier
Bisphenol A (BPA) can affect reproductive function, but its mechanism of reproductive
toxicity is unclear, and the effect of BPA on the onset of puberty was inconsistent. The main …
toxicity is unclear, and the effect of BPA on the onset of puberty was inconsistent. The main …