The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

We review three approaches to the genetic analysis of the biology and pathobiology of
human aging. The first and so far the best-developed is the search for the biochemical …

Abstract In model organisms, over 2,000 genes have been shown to modulate aging, the
collection of which we call the 'gerontome'. Although some individual aging-related genes …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

Once thought to be an extremely complex conundrum of weak genetic and environmental
effects, exceptional longevity is beginning to yield genetic findings. Numerous lower …

Aging is the single largest risk factor for chronic disease. Studies in model organisms have
identified conserved pathways that modulate aging rate and the onset and progression of …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

By the mid 1970s, the mechanisms by which ageing can evolve had a secure theoretical
basis in population genetics. Here, we discuss how subsequent evolutionary work has …

Aging is a complex, challenging phenomenon that requires multiple, interdisciplinary
approaches to unravel its puzzles. To assist basic research on aging, we developed the …