Three-dimensional multispecies nonlinear tumor growth—II: tumor invasion and angiogenesis

HB Frieboes, F Jin, YL Chuang, SM Wise… - Journal of theoretical …, 2010 - Elsevier
We extend the diffuse interface model developed in Wise et al.(2008) to study nonlinear
tumor growth in 3-D. Extensions include the tracking of multiple viable cell species …

Three-dimensional multispecies nonlinear tumor growth—I: model and numerical method

SM Wise, JS Lowengrub, HB Frieboes… - Journal of theoretical …, 2008 - Elsevier
This is the first paper in a two-part series in which we develop, analyze, and simulate a
diffuse interface continuum model of multispecies tumor growth and tumor-induced …

Nonlinear simulation of the effect of microenvironment on tumor growth

P Macklin, J Lowengrub - Journal of theoretical biology, 2007 - Elsevier
In this paper, we present and investigate a model for solid tumor growth that incorporates
features of the tumor microenvironment. Using analysis and nonlinear numerical …

Nonlinear modelling of cancer: bridging the gap between cells and tumours

JS Lowengrub, HB Frieboes, F Jin, YL Chuang, X Li… - …, 2009 - iopscience.iop.org
Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Multiparameter computational modeling of tumor invasion

EL Bearer, JS Lowengrub, HB Frieboes, YL Chuang… - Cancer research, 2009 - AACR
Clinical outcome prognostication in oncology is a guiding principle in therapeutic choice. A
wealth of qualitative empirical evidence links disease progression with tumor morphology …

Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions

H Perfahl, HM Byrne, T Chen, V Estrella, T Alarcón… - PloS one, 2011 - journals.plos.org
We investigate a three-dimensional multiscale model of vascular tumour growth, which
couples blood flow, angiogenesis, vascular remodelling, nutrient/growth factor transport …

Multiscale modelling and nonlinear simulation of vascular tumour growth

P Macklin, S McDougall, ARA Anderson… - Journal of mathematical …, 2009 - Springer
In this article, we present a new multiscale mathematical model for solid tumour growth
which couples an improved model of tumour invasion with a model of tumour-induced …

Multiscale models for the growth of avascular tumors

ML Martins, SC Ferreira Jr, MJ Vilela - Physics of Life Reviews, 2007 - Elsevier
In the past 30 years we have witnessed an extraordinary progress on the research in the
molecular biology of cancer, but its medical treatment, widely based on empirically …

Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models

V Quaranta, KA Rejniak, P Gerlee… - Seminars in Cancer …, 2008 - Elsevier
In this review we summarize our recent efforts using mathematical modeling and
computation to simulate cancer invasion, with a special emphasis on the tumor …

Nonlinear simulation of tumor growth

V Cristini, J Lowengrub, Q Nie - Journal of mathematical biology, 2003 - Springer
We study solid tumor (carcinoma) growth in the nonlinear regime using boundary-integral
simulations. The tumor core is nonnecrotic and no inhibitor chemical species are present. A …