Oxidative Stress and Neurodegeneration: Insights and Therapeutic Strategies for Parkinson's Disease

E Bej, P Cesare, AR Volpe, M d'Angelo… - Neurology …, 2024 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative condition marked by the
gradual deterioration of dopaminergic neurons in the substantia nigra. Oxidative stress has …

Oxidative stress in Parkinson's disease: role in neurodegeneration and targets for therapeutics

R Banerjee, NA Kaidery, B Thomas - Oxidative Stress: Diagnostics …, 2015 - ACS Publications
Parkinson's disease (PD) is a prevalent neurodegenerative movement disorder affecting
millions of predominantly elderly people worldwide and remains essentially untreatable. The …

Anti-oxidants in Parkinson's disease therapy: a critical point of view

R Filograna, M Beltramini, L Bubacco… - Current …, 2016 - ingentaconnect.com
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized
by the preferential death of dopaminergic (DAergic) neurons in the Substantia Nigra. The …

Evidence for oxidative pathways in the pathogenesis of PD: are antioxidants candidate drugs to ameliorate disease progression?

A Leathem, T Ortiz-Cerda, JM Dennis… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a
complex and variable interplay between elements including age, genetic, and …

The role of oxidative stress in Parkinson's disease

KH Chang, CM Chen - Antioxidants, 2020 - mdpi.com
Parkinson's disease (PD) is caused by progressive neurodegeneration of dopaminergic
(DAergic) neurons with abnormal accumulation of α-synuclein in substantia nigra (SN) …

Antioxidant therapeutics in Parkinson's disease: Current challenges and opportunities

AP Duarte-Jurado, Y Gopar-Cuevas… - Antioxidants, 2021 - mdpi.com
Oxidative stress is considered one of the pathological mechanisms that cause Parkinson's
disease (PD), which has led to the investigation of several antioxidants molecules as a …

Oxidative stress and cellular pathologies in Parkinson's disease

L Puspita, SY Chung, J Shim - Molecular brain, 2017 - Springer
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …

Oxidative stress and Parkinson's disease: conflict of oxidant-antioxidant systems

M Hemmati-Dinarvand, M Valilo… - Neuroscience …, 2019 - Elsevier
Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is
diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are …

Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance

C Zhou, Y Huang, S Przedborski - … of the new York Academy of …, 2008 - Wiley Online Library
Parkinson's disease (PD) is a common adult‐onset neurodegenerative disorder. Typically
PD is a sporadic neurological disorder, and over time affected patients see their disability …

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

BG Trist, DJ Hare, KL Double - Aging cell, 2019 - Wiley Online Library
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …