Small extracellular vesicles (sEVs) participate in the pathological progression of high
glucose (HG)-induced kidney injury, which is closely related to diabetic nephropathy. How …

Renal tubular cell injury by exposure to high glucose (HG) stimulation mainly accounts for
diabetic nephropathy (DN). To understand the mechanism of injury by HG, quantitative …

Extracellular vesicles (EVs) are emerging as important mediators of cell–cell communication
as well as potential disease biomarkers and drug delivery vehicles. However, the …

Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a
chronic progressive condition. It is also a common cause of end-stage renal disease …

Glomerular hypertension is an important factor exacerbating glomerular diseases to end-
stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in …

Small extracellular vesicles (sEVs) play a crucial role in local and distant cell
communication. The intrinsic properties of sEVs make them compatible biomaterials for drug …

Extracellular vesicles (EVs) have drawn attention as promising therapeutic agents whose
characteristics resemble their parent cells. However, their practical utility is limited by low EV …

Cells release extracellular vesicles (EVs) as the carriers for intercellular communications to
regulate life activities. Particularly, it is increasingly apparent that mechanical forces play an …

Glomerular mesangial cells (MCs) are centrally located in the glomerulus. MCs control not
only glomerular filtration, but also the response to local injury, including cell proliferation and …

Podocytes, localized in the glomerulus, are a prognostic factor of proteinuria in kidney
disease and are exposed to distinct physiological stimuli from basal to apical filtration flow …