Drug repositioning based on tripartite cross-network embedding and graph convolutional network

P Zeng, B Zhang, A Liu, Y Meng, X Tang, J Yang… - Expert Systems with …, 2024 - Elsevier
Drug-disease association prediction is an important part of drug discovery, which can help
researchers uncover potential drug candidates and disease targets more accurately to deal …

SLGCN: Structure-enhanced line graph convolutional network for predicting drug–disease associations

BM Liu, YL Gao, F Li, CH Zheng, JX Liu - Knowledge-Based Systems, 2024 - Elsevier
Drug repositioning is a rapidly growing strategy in drug discovery, as the time and cost
needed are considerably less compared to developing new drugs. In addition to traditional …

REDDA: Integrating multiple biological relations to heterogeneous graph neural network for drug-disease association prediction

Y Gu, S Zheng, Q Yin, R Jiang, J Li - Computers in biology and medicine, 2022 - Elsevier
Computational drug repositioning is an effective way to find new indications for existing
drugs, thus can accelerate drug development and reduce experimental costs. Recently …

A multi-graph deep learning model for predicting drug-disease associations

BW Zhao, ZH You, L Hu, L Wong, BY Ji… - … Computing Theories and …, 2021 - Springer
Computational drug repositioning is essential in drug discovery and development. The
previous methods basically utilized matrix calculation. Although they had certain effects, they …

Drug repositioning based on weighted local information augmented graph neural network

Y Meng, Y Wang, J Xu, C Lu, X Tang… - Briefings in …, 2024 - academic.oup.com
Drug repositioning, the strategy of redirecting existing drugs to new therapeutic purposes, is
pivotal in accelerating drug discovery. While many studies have engaged in modeling …

Predicting drug–drug interactions by graph convolutional network with multi-kernel

F Wang, X Lei, B Liao, FX Wu - Briefings in Bioinformatics, 2022 - academic.oup.com
Drug repositioning is proposed to find novel usages for existing drugs. Among many types of
drug repositioning approaches, predicting drug–drug interactions (DDIs) helps explore the …

Graph convolutional autoencoder and generative adversarial network-based method for predicting drug-target interactions

C Sun, P Xuan, T Zhang, Y Ye - IEEE/ACM transactions on …, 2020 - ieeexplore.ieee.org
The computational prediction of novel drug-target interactions (DTIs) may effectively speed
up the process of drug repositioning and reduce its costs. Most previous methods integrated …

Drug repositioning based on the heterogeneous information fusion graph convolutional network

L Cai, C Lu, J Xu, Y Meng, P Wang, X Fu… - Briefings in …, 2021 - academic.oup.com
In silico reuse of old drugs (also known as drug repositioning) to treat common and rare
diseases is increasingly becoming an attractive proposition because it involves the use of de …

[HTML][HTML] MGRL: predicting drug-disease associations based on multi-graph representation learning

BW Zhao, ZH You, L Wong, P Zhang, HY Li… - Frontiers in …, 2021 - frontiersin.org
Drug repositioning is an application-based solution based on mining existing drugs to find
new targets, quickly discovering new drug-disease associations, and reducing the risk of …

A novel drug repositioning model based on heterogeneous graph convolutional network via multi-task learning

S Ye, W Zhao, X Shen, X Jiang… - 2022 IEEE International …, 2022 - ieeexplore.ieee.org
Compared with traditional methods, drug repositioning is a viable solution to drug discovery.
Drug repositioning usually applies the procedure of drug-disease associations (DDAs) …