Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design

Y Peng, N Du, Y Lei, S Dorje, J Qi, T Luo, GF Gao… - The EMBO …, 2020 - embopress.org
Abstract COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …

Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein

R Zhou, R Zeng, A von Brunn, J Lei - Molecular biomedicine, 2020 - Springer
The newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
resulted in a global human health crisis. The CoV nucleocapsid (N) protein plays essential …

[HTML][HTML] Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein

X Luan, X Li, Y Li, G Su, W Yin, Y Jiang, N Xu, F Wang… - Science Bulletin, 2022 - Elsevier
Nucleocapsid (N) protein plays crucial roles in the life cycle of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), including the formation of ribonucleoprotein (RNP) …

[HTML][HTML] Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

S Kang, M Yang, Z Hong, L Zhang, Z Huang… - … Pharmaceutica Sinica B, 2020 - Elsevier
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually
lead to worldwide human infections and deaths. Currently, there is no specific viral protein …

The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation

Z Bai, Y Cao, W Liu, J Li - Viruses, 2021 - mdpi.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …

Atomic-resolution structure of SARS-CoV-2 nucleocapsid protein N-terminal domain

S Sarkar, B Runge, RW Russell… - Journal of the …, 2022 - ACS Publications
The nucleocapsid (N) protein is one of the four structural proteins of the SARS-CoV-2 virus
and plays a crucial role in viral genome organization and, hence, replication and …

Architecture and self‐assembly of the SARS‐CoV‐2 nucleocapsid protein

Q Ye, AMV West, S Silletti, KD Corbett - Protein Science, 2020 - Wiley Online Library
The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …

High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory …

L Zinzula, J Basquin, S Bohn, F Beck, S Klumpe… - Biochemical and …, 2021 - Elsevier
Unprecedented by number of casualties and socio-economic burden occurring worldwide,
the coronavirus disease 2019 (Covid-19) pandemic caused by the severe acute respiratory …

SARS-CoV-2 nucleocapsid and Nsp3 binding: an in silico study

MT Khan, MT Zeb, H Ahsan, A Ahmed, A Ali… - Archives of …, 2021 - Springer
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) belongs to the single-stranded
positive-sense RNA family. The virus contains a large genome that encodes four structural …

[HTML][HTML] A proposed role for the SARS‐CoV‐2 nucleocapsid protein in the formation and regulation of biomolecular condensates

SM Cascarina, ED Ross - The FASEB Journal, 2020 - ncbi.nlm.nih.gov
To date, the recently discovered SARS‐CoV‐2 virus has afflicted> 6.9 million people
worldwide and disrupted the global economy. Development of effective vaccines or …