Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)

AR Bourgonje, AE Abdulle, W Timens… - The Journal of …, 2020 - Wiley Online Library
Abstract Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional
host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus …

[HTML][HTML] COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

S Beyerstedt, EB Casaro, ÉB Rangel - European journal of clinical …, 2021 - Springer
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-
converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell …

Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19

H Cheng, Y Wang, GQ Wang - Journal of medical virology, 2020 - Wiley Online Library
This article reviews the correlation between angiotensin‐converting enzyme 2 (ACE2) and
severe risk factors for coronavirus disease 2019 (COVID‐19) and the possible mechanisms …

[HTML][HTML] Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

W Ni, X Yang, D Yang, J Bao, R Li, Y Xiao, C Hou… - Critical Care, 2020 - Springer
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global …

[HTML][HTML] The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

R Rodrigues, S Costa de Oliveira - Microorganisms, 2021 - mdpi.com
Angiotensin-Converting Enzyme 2 (ACE2) has been proved to be the main host cell receptor
for the binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …

[HTML][HTML] Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV

S Li, Z Tang, Z Li, X Liu - European Journal of Clinical Microbiology & …, 2020 - Springer
Since December 2019, the infection of the new coronavirus (COVID-19) caused an outbreak
of new coronavirus pneumonia in Wuhan, China, and caused great public concern. Both …

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2)

AE Zemlin, OJ Wiese - Annals of clinical biochemistry, 2020 - journals.sagepub.com
Since the first cases of atypical pneumonia linked to the Huanan Seafood Wholesale Market
in Wuhan, China, were described in late December 2019, the global landscape has …

[HTML][HTML] COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi-organ disease

R Gan, NP Rosoman, DJE Henshaw, EP Noble… - Medical hypotheses, 2020 - Elsevier
Abstract SARS-CoV-2, the agent of COVID-19, shares a lineage with SARS-CoV-1, and a
common fatal pulmonary profile but with striking differences in presentation, clinical course …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …