Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

K Ralhan, KA Iyer, LL Diaz, R Bird, A Maind… - ACS Infectious …, 2024 - ACS Publications
The development of effective antibacterial solutions has become paramount in maintaining
global health in this era of increasing bacterial threats and rampant antibiotic resistance …

Antibiotics special issue: challenges and opportunities in antibiotic discovery and development

MAT Blaskovich - ACS Infectious Diseases, 2020 - ACS Publications
Antimicrobial resistance (AMR) has received increasing global attention over the past
decade. The lack of antibiotics in the clinical pipeline is a direct result of the discouraging …

Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Solving the antibiotic crisis

GD Wright - ACS Infectious Diseases, 2015 - ACS Publications
Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically,
despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …

Progress report: Antimicrobial drug discovery in the resistance era

P Shinu, AKA Mouslem, AB Nair, KN Venugopala… - Pharmaceuticals, 2022 - mdpi.com
Antibiotic resistance continues to be a most serious threat to public health. This situation
demands that the scientific community increase their efforts for the discovery of alternative …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Antibiotics: Past, Present, Future, and Clinical Pipeline

R Singh, V Tandon - Recent Advances in Pharmaceutical Innovation and …, 2023 - Springer
A significant threat to global public health is antimicrobial resistance (AMR). The estimated
cause of at least 700,000 deaths each year worldwide is medication-resistant bacterial …

Emerging non-traditional approaches to combat antibiotic resistance

AN Konwar, SN Hazarika, P Bharadwaj, D Thakur - Current Microbiology, 2022 - Springer
An increasing number of bacterial pathogens are acquiring resistance to the commonly used
antibiotics. This has spurred a global threat leading to a resistance era and has penetrated …

Antimicrobial resistance: A multifaceted problem with multipronged solutions

T Gil‐Gil, P Laborda, F Sanz‐García… - …, 2019 - Wiley Online Library
Infectious diseases still stand as a major cause of morbidity and mortality, and this problem
can be worsened with the current antimicrobial resistance crisis. To tackle this crisis more …

Novel targets and mechanisms in antimicrobial drug discovery

D Tondi - Antibiotics, 2021 - mdpi.com
The spread of infections resistant to available anti-infective drugs is a serious menace to
human health. WHO predicts that in less than 30 years, microbial resistance will become the …