The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

Recent research suggests a complex role for microglia not only in Parkinson's disease but in
other disorders involving alpha-synuclein aggregation, such as multiple system atrophy. In …

The role of neuroinflammation and the adaptive immune system in PD (Parkinson's disease)
has been the subject of intense investigation in recent years, both in animal models of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …

Microglial activation and adaptive immunity have been implicated in the neurodegenerative
processes in Parkinson disease. It has been proposed that these responses may be …

Although almost 50 years have passed since impaired dopaminergic transmission was
identified as the main neurochemical defect in Parkinson's disease (PD), the cause of the …

Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …

The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …

Abstract α-Synuclein, a key pathological component of Parkinson's disease, has been
implicated in the activation of the innate and adaptive immune system. This immune …

• Introduction• Importance of inflammation processes in PD pathology• Stimulation of
microglia by αSyn• αSyn‐triggered stimulation of the innate immune system• Other proteins …