Purpose Dry eye disease is characterized by loss of tear film stability. OC-01 (varenicline
solution) is a small-molecule nicotinic acetylcholine receptor agonist administered as a …

Purpose To evaluate the efficacy and safety of OC-01 (varenicline solution) nasal spray for
treatment of patients with dry eye disease. Design Randomized, multicenter, double …

Purpose: The purpose of this trial was to evaluate the safety and efficacy of OC-01
(varenicline solution), a nicotinic acetylcholine receptor agonist nasal spray, on signs and …

Increasing endogenous tear film production via pharmacological neuroactivation of the
nasolacrimal reflex [NLR; also known as the trigeminal parasympathetic pathway (TPP)] is a …

Purpose: NOV03 has a unique dual mode of action to address dry eye disease (DED)
associated with meibomian gland dysfunction. SEECASE evaluated the efficacy, safety, and …

Purpose: The aim of this prospective, randomized, clinical, single-center study was to
compare the safety and efficacy of 2 ocular surface lubricant eye drops: preservative-free …

Objective To evaluate the efficacy and safety of NOV03 (perfluorohexyloctane) ophthalmic
drop in patients with dry eye disease (DED) associated with meibomian gland dysfunction …

Purpose: The effective management of dry eye must include a clinically meaningful
reduction in ocular staining. Evaluations of corneal and conjunctival staining and other …

Purpose To evaluate and compare the efficacy and safety of two investigational artificial tear
formulations (CHO-1 and CHO-2) containing carmellose sodium, hyaluronic acid at different …

Purpose Artificial tears are the first line of therapy for dry eye disease (DED) and are also the
most frequently used treatment approach for this common condition. Despite this, there are …