Enzyme-responsive microneedle patch for bacterial infection and accelerated healing of diabetic wounds

S Wu, B Qin, X Tang, T Cui, S Yin, H Dong, Y Liu… - Chemical Engineering …, 2023 - Elsevier
Chronic diabetic wounds are caused by an array of pathologies. Pathogenic bacteria such
as S. aureus can easily invade hosts with deficient immunity. In this study, we developed a …

Multifunctional Double‐Layer and Dual Drug‐Loaded Microneedle Patch Promotes Diabetic Wound Healing

W Liu, X Zhai, X Zhao, Y Cai, X Zhang… - Advanced …, 2023 - Wiley Online Library
Chronic nonhealing diabetic wounds are a serious complication of diabetes, with a high
morbidity rate that can cause disability or death. The long period of inflammation and …

An antibacterial and proangiogenic double-layer drug-loaded microneedle patch for accelerating diabetic wound healing

S Gao, W Zhang, X Zhai, X Zhao, J Wang… - Biomaterials …, 2023 - pubs.rsc.org
Diabetic wounds are difficult to heal because of bacterial infections and insufficient
angiogenesis. Herein, we report a double-layer drug-loaded microneedle patch with …

A multi-enzyme cascade microneedle reaction system for hierarchically MRSA biofilm elimination and diabetic wound healing

X Yu, J Zhao, X Ma, D Fan - Chemical Engineering Journal, 2023 - Elsevier
The existence of biofilm remains a significant impediment to the healing of chronic wounds,
including diabetic wounds. The dense extracellular polymeric substance (EPS) barrier of …

An Integrated Therapeutic and Preventive Nanozyme‐Based Microneedle for Biofilm‐Infected Diabetic Wound Healing

C Sun, X Zhou, C Liu, S Deng, Y Song… - Advanced …, 2023 - Wiley Online Library
The healing of biofilm‐infected diabetic wounds characterized by a deteriorative tissue
microenvironment represents a substantial clinical challenge. Current treatments remain …

“one stone four birds” strategy of advanced hydrogel system based on eight-arm nanocages to promote chronic wound healing in diabetes

W Li, M Kong, T Yang, J Li, H Sun, Z Li, Q Wang… - Chemical Engineering …, 2023 - Elsevier
Due to the frequent occurrence of microvascular impairments and persistent bacterial
infections in wounds of diabetic patients, the resulting hindered wound healing process …

Claw-inspired microneedle patches with liquid metal encapsulation for accelerating incisional wound healing

X Zhang, G Chen, L Sun, F Ye, X Shen… - Chemical Engineering …, 2021 - Elsevier
Microneedles are providing an emerging strategy for promoting wound healing. Attempts to
develop this technology tend to impart them with additional functions. Herein, inspired by the …

Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria

S Wang, H Zheng, L Zhou, F Cheng, Z Liu, H Zhang… - Nano …, 2020 - ACS Publications
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-
resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound …

[HTML][HTML] Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

P Wang, J Wu, H Yang, H Liu, T Yao, C Liu, Y Gong… - Bioactive Materials, 2023 - Elsevier
Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to
delayed wound healing associated with consistent pro-inflammatory M1 polarization …

Antibacterial, adhesive, and MSC exosomes encapsulated microneedles with spatio-temporal variation functions for diabetic wound healing

J Gan, X Zhang, W Ma, Y Zhao, L Sun - Nano Today, 2022 - Elsevier
Chronic wounds affect healthcare systems and increase the risk of infection. Despite the
clinical demand for improving healing, an effective and safe therapeutic approach is still …