Imbalanced immune response of T-cell and B-cell subsets in patients with moderate and severe COVID-19
A Golovkin, O Kalinina, V Bezrukikh, A Aquino… - Viruses, 2021 - mdpi.com
Background: The immunological changes associated with COVID-19 are largely unknown.
Methods: Patients with COVID-19 showing moderate (n= 18; SpO2> 93%, respiratory rate> …
Methods: Patients with COVID-19 showing moderate (n= 18; SpO2> 93%, respiratory rate> …
Characteristics of lymphocyte subset alterations in COVID-19 patients with different levels of disease severity
W Dai, A Zhong, Q Qiao, J Wu, W Li, Q Wu, H Zhou… - Virology journal, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disorder
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had …
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had …
Negative clinical evolution in COVID-19 patients is frequently accompanied with an increased proportion of undifferentiated Th cells and a strong underrepresentation …
JF Gutiérrez-Bautista, A Rodriguez-Nicolas… - Frontiers in …, 2020 - frontiersin.org
The severity of SARS-CoV-2 infection has been related to uncontrolled inflammatory innate
responses and impaired adaptive immune responses mostly due to exhausted T …
responses and impaired adaptive immune responses mostly due to exhausted T …
Hyperinflammatory state and low T1 adaptive immune response in severe and critical acute COVID-19 patients
M Garcia-Gasalla, M Berman-Riu, J Pons… - Frontiers in …, 2022 - frontiersin.org
Background A better understanding of COVID-19 immunopathology is needed to identify the
most vulnerable patients and improve treatment options. Objective We aimed to identify …
most vulnerable patients and improve treatment options. Objective We aimed to identify …
Immunosuppression as a hallmark of critical COVID-19: prospective study
E Kalicińska, D Szymczak, A Zińczuk, B Adamik… - Cells, 2021 - mdpi.com
The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an
impact on the course of COVID-19, and play a role in the clinical outcome of the disease …
impact on the course of COVID-19, and play a role in the clinical outcome of the disease …
Alterations in B cell and follicular T-helper cell subsets in patients with acute COVID-19 and COVID-19 convalescents
IV Kudryavtsev, NA Arsentieva, OK Batsunov… - Current issues in …, 2021 - mdpi.com
Background. Humoral immunity requires interaction between B cell and T follicular helper
cells (Tfh) to produce effective immune response, but the data regarding a role of B cells and …
cells (Tfh) to produce effective immune response, but the data regarding a role of B cells and …
Immune characteristics of severe and critical COVID-19 patients
L Yang, J Gou, J Gao, L Huang, Z Zhu, S Ji… - Signal transduction and …, 2020 - nature.com
Recently, the novel coronavirus disease (COVID-19) has broken out worldwide, 1 with rapid
increase of infected patients. COVID-19 dominantly leads to pneumonia. 2 Among these …
increase of infected patients. COVID-19 dominantly leads to pneumonia. 2 Among these …
Characterizing the immune responses of those who survived or succumbed to COVID-19: Can immunological signatures predict outcome?
Background Immunodeficiency has pivotal role in the pathogenesis of coronavirus disease
2019 (COVID-19). Several studies have indicated defects in the immune system of COVID …
2019 (COVID-19). Several studies have indicated defects in the immune system of COVID …
Alterations in T and B cell function persist in convalescent COVID-19 patients
HA Shuwa, TN Shaw, SB Knight, K Wemyss… - Med, 2021 - cell.com
Background Emerging studies indicate that some coronavirus disease 2019 (COVID-19)
patients suffer from persistent symptoms, including breathlessness and chronic fatigue; …
patients suffer from persistent symptoms, including breathlessness and chronic fatigue; …
The age-dependent role of Th22, Tc22, and Tc17 cells in the severity of pneumonia in COVID-19 immunopathogenesis
Coronavirus disease 2019 (COVID-19) has clinical manifestations ranging from mild
symptoms to respiratory failure, septic shock, and multi-organ failure. Lymphocytes are …
symptoms to respiratory failure, septic shock, and multi-organ failure. Lymphocytes are …