Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Synthetic gene delivery vectors are gaining increasing importance in gene therapy as an
alternative to recombinant viruses. Among the various types of non-viral vectors, cationic …

Among other strategies, the use of cationic lipids as autoassembling vehicles for non viral
DNA transfection has received considerable attention. An exponentially growing litterature …

Twenty years after gene therapy was introduced in the clinic, advances in the technique
continue to garner headlines as successes pique the interest of clinicians, researchers, and …

Over the last several years, various gene delivery systems have been developed for gene
therapy applications. Although viral vector-based gene therapy has led to the greatest …

Synthetic cationic lipids, which form complexes (lipoplexes) with polyanionic DNA, are
presently the most widely used constituents of nonviral gene carriers. A large number of …

Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Gene therapy will change medicine by treating the diseases at their core levels
revolutionizing the way to deliver functional proteins. The development of this technology …

Recent rapid developments in genomics will likely lead to a rapid expansion in identifying
defective genes causing a variety of diseases, implying a vast increase in the number of …

Realization of the potential of nucleic acids as drugs is intricately linked to their in vivo
delivery. Cationic lipids demonstrated tremendous potential as safe, efficient and scalable in …